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| 1 | Initial 3d-models:
Semi-Automated IVUS method
MRI/CT initial algorithms stages
Stent Models
| 02/2009 (M6)
| Demonstration of the initial approach to 3d artery and arterial tree reconstruction and Demonstration of the initial 3d stent models that will be used in blood flow analysis
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| 2 | Blood Flow Analysis on Un-stented Arteries
| 03/2009 (M7)
| Demonstration of the blood flow analysis computation algorithms used and tested on un-stented 3d arterial models
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| 3 | Initial Plaque Characterisation Algorithm
| 05/2009 (M9)
| Demonstration of the initial approach to plaque characterisation based on IVUS images.
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| 4 | Patient Specific 3D anatomical models (IVUS, MRI, CT, stented and unstented)
| 08/2009 (M12)
| Demonstration of the final and fully automated algorithms for the 3d reconstruction of artery and arterial tree from all image modalities. The models will also incorporate stented artery segments.
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| 5 | Blood Flow Analysis on Stented Arteries
| 08/2009 (M12)
| Demonstration of the refined blood flow analysis computation algorithms used and tested on stented 3d arterial models
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| 6 | Generic Blood Particle Dynamics on un-stented Arteries
| 08/2009 (M12)
| Demonstration of particle dynamics simulation on unstented segments of arteries
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| 7 | ARTML description
| 08/2009 (M12)
| Description of the ARTML structures, properties and functions developed for the description of the Wall Adhesion Biological Process
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| 8 | Lab Experiment Findings
| 01/2012 (M41)
| Report describing both qualitative and quantitive the initial findings from the laboratory experiments on the endothelium and gene expression changes caused by blood flow and shear strees.
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| 9 | Plaque Characterisation Algorithm
| 04/2012 (M44)
| Demonstration of the final algorithms used for plaque characterisation, which provide the most accurate and useful results among the different tested methods.
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| 10 | First Integrated Patient Specific Model Prototype on Un-stented Arteries
| 02/2010 (M18)
| Demonstration of an early integrated three-level prototype including patient anatomy, blood flow and particle dynamics on un-stented arteries
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| 11 | Generic Blood Particle Dynamics on Stented Arteries
| 01/2010 (M17)
| Demonstration of particle dynamics simulation on stented segments of arteries
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| 12 | Treatment Decision Support Design and Architecture
| 04/2010 (M20)
| Deliverable describing the design guidelines for the treatment decision support tool
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| 13 | Interventional Decision Support Design and Architecture
| 05/2010 (M21)
| Deliverable describing the design guidelines for the interventional decision support tool, as well as the training tool
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| 14 | Complete Bio-anatomical model tested and adapted to animal data
| 09/2012 (M49)
| Integrated anatomical model with blood flow, particle dynamics simulation and simulation of the wall adhesion process based on the data collected from the animal studies
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| 15 | Complete Bio-anatomical model tested and adapted to human data
| 09/2012 (M49)
| Integrated anatomical model with blood flow, particle dynamics simulation and simulation of the wall adhesion process based on the data collected from the human studies
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| 16 | The ARTreat System and Applications Integrated and technically tested
| 01/2013 (M53)
| Demonstration of final functional versions of the treatment decision support, interventional decision support and training application.
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| 17 | The ARTreat Validation
| 09/2012 (M49)
| Report on the validation of the provided ARTreat applications
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| 18 | The Final ARTreat Proof of Concept Study
| 11/2012 (M51)
| Updates, additions, corrections and modifications of the proof of concept study
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| 19 | Public availability of models
| 11/2012 (M51)
| The basic results of the models developed in WP3 and WP5 will be made publicly available to the scientific community with all appropriate documentation through the ARTreat website and the VPH-NOE
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Milestones